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The centromere links a pair of sister chromatids together during cell division. This constricted region of chromosome connects the sister chromatids, creating a short arm (p) and a long arm (q) on the chromatids. During mitosis, spindle fibers attach to the centromere via the kinetochore.. The physical role of the centromere is to act as the site of assembly of the kinetochores – a .

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Mar 18,  · Definition Nanocapsules: in which the drug is confined to an aqueous or oily core surrounded by a shell-like wall. Alternatively, the drug can be covalently attached to the surface or into the matrix 8. Bioadhesion, 2) translocation through the mucosa and 3) transit and direct fecal elimination. Mar 08,  · Translocation Down syndrome. Down syndrome can also occur when a portion of chromosome 21 becomes attached (translocated) onto another chromosome, before or at conception. but can pass an unbalanced translocation on to children, causing Down syndrome in the children. Risk factors. Some parents have a greater risk of having a baby with . Individuals with 3p deletion syndrome associated with an unbalanced translocation are missing genetic material from the short arm of chromosome 3, which results in the signs and symptoms of this disorder. Wallerstein R. Deletion of 3p in a patient with intellectual disability and dysmorphic features with further definition of a critical.

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However, as this translocation is passed to the next generation, it can become unbalanced. People who inherit an unbalanced translocation involving chromosome 21 may have extra genetic material from chromosome 21, which causes Down syndrome. Like trisomy 21, mosaic Down syndrome is not inherited. People with translocation Down syndrome can inherit the condition from an unaffected parent. The parent carries a rearrangement of genetic material between chromosome 21 and another chromosome. This rearrangement is called a balanced translocation. No genetic material is gained or lost in a balanced translocation, so these chromosomal changes.